MOTS-c research: overview and resources
What MOTS-c research material is, how it is characterized, and where to find every specification, method, lot record and reference MOTS-c Labs publishes about it.
What is MOTS-c?
MOTS-c is a 16-residue peptide, MRWQEMGYIFYPRKLR, whose sequence is encoded within the mitochondrial gene for 12S ribosomal RNA (MT-RNR1) rather than in nuclear DNA. Its name is an abbreviation of "mitochondrial open reading frame of the 12S rRNA type-c". It belongs to a small group of mitochondrial-derived peptides identified in the last decade and is studied in cell and animal models of metabolic regulation. The synthetic peptide supplied here has the same 16-residue sequence with free termini.
MOTS-c Labs supplies it as a lyophilized powder in 10 mg and 40 mg vials. Each lot is tested by ILS Laboratories for HPLC purity, identity against a reference standard and net content, with a fentanyl screen, and the certificate is published here before sale through Klow.bio.
What is MOTS-c research material?
MOTS-c research material is MOTS-c supplied for laboratory research (C101H152N28O22S2, 2174.62 g/mol) in lyophilized powder form, sold by lot. Each lot's identity, purity and net content are documented by an independent laboratory in a published certificate of analysis.
How is MOTS-c characterized?
Three questions are answered for every lot, each by a different method:
- Is it the right compound? The laboratory runs the sample and a reference standard of the named compound under the same HPLC conditions; identity is confirmed when the main peak elutes at the reference standard’s retention time.
- How much of the sample is that compound? HPLC-UV reports the main peak's share of detected peak area. Current lots: 99.90%.
- How much peptide is in the vial? Net content is measured directly.
Endotoxin (LAL) and microbial DNA (PCR) results are added where those tests are run.
What has not been established
A certificate of analysis describes the specific sample tested on its test date. It does not establish stability afterward, sequence order beyond what mass confirmation shows, results for other lots, or suitability for any particular purpose.
MOTS-c at a glance
- Product
- MOTS-c
- Type
- 16-residue mitochondrial-derived peptide, 16 residues
- Also known as
- Mitochondrial open reading frame of the 12S rRNA type-c
- CAS number
- 1627580-64-6
- Molecular formula
- C101H152N28O22S2
- Molecular weight
- 2174.62 g/mol (average)
- Form
- Lyophilized powder
- Vial sizes
- 10 mg, 40 mg
- Purity, current lots
- 99.90% (HPLC-UV)
- Purity specification
- ≥95%
- Identity
- Confirmed by HPLC retention-time match on every lot
- Testing laboratory
- ILS Laboratories (independent)
- Current lot
- KB-44745, reported Sep 11, 2026
- Operated by
- Klow Labs LLC, Chicago, IL
- Where to order
- klow.bio
MOTS-c research resources
Every MOTS-c resource on motsc.bio, organized from chemistry to documentation.
MOTS-c specifications
Formula, molecular weight, sequence, modifications and release specification.
QualityQuality and supply chain
Sourcing, specifications, batch documentation and release.
TestingAnalytical testing
How every lot is tested, reviewed and released.
TestingHPLC analysis of MOTS-c
Retention time, peaks, area normalization and results by lot.
DocumentationCertificates of analysis
Every lot's full results, plus the complete testing records.
DocumentationHow to read a MOTS-c COA
What each section means and what a COA does and doesn't establish.
DocumentationVerify a lot
Look up any MOTS-c lot by the number on the vial.
AnalysisPurity, content and net content
Three different numbers, kept apart.
HandlingStorage and stability
Degradation pathways and lyophilized peptide handling.
ReferenceGlossary
Definitions for every term on a MOTS-c certificate.
Research materialMOTS-c research material
Sizes, current lots and availability. Purchasing is handled through Klow.bio.
Research references
Published sources
- PubChem: MOTS-c. National Library of Medicine, NIH. pubchem.ncbi.nlm.nih.gov/compound/155885767
- NCBI Gene: MT-RNR1 (mitochondrially encoded 12S rRNA). National Center for Biotechnology Information, NIH. www.ncbi.nlm.nih.gov/gene/4549
- Wilm M. Principles of electrospray ionization. Mol Cell Proteomics. 2011. PMC3134074. pmc.ncbi.nlm.nih.gov/articles/PMC3134074
- U.S. FDA. Q2(R2) Validation of Analytical Procedures. 2024. fda.gov
- U.S. FDA. Pyrogen and Endotoxins Testing: Questions and Answers. Revised 2026. fda.gov
MOTS-c Labs analytical documentation
- Lot KB-44745: 10 mg, 99.90% purity, reported Sep 11, 2026
- Lot KB-44745: 10 mg, 99.90% purity, reported Sep 11, 2026
- MOTS-c testing records (all tests, all lots; CSV available)
Editorial scope
MOTS-c Labs research content covers molecular characteristics, peptide structure, analytical chemistry, purity and identity testing, certificates of analysis, lot documentation and laboratory storage and handling.
It does not cover dosing, administration instructions, protocols, personal use or medical advice.
Latest updates
Buy MOTS-c
10 mg and 40 mg vials. Current lot KB-44745 tested at 99.90% purity with identity confirmed by HPLC retention-time match against a reference standard. Current purchasing is available through Klow.bio.