MOTS-c from MOTS-c Labs is a 16-residue mitochondrial-derived peptide, supplied as a lyophilized powder in 10 mg and 40 mg vials. Every lot is independently tested, and its results are published as a lot record with the certificate PDF.
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Specifications and current testing status in one place.
MOTS-c is a 16-residue peptide, MRWQEMGYIFYPRKLR, whose sequence is encoded within the mitochondrial gene for 12S ribosomal RNA (MT-RNR1) rather than in nuclear DNA. Its name is an abbreviation of "mitochondrial open reading frame of the 12S rRNA type-c". It belongs to a small group of mitochondrial-derived peptides identified in the last decade and is studied in cell and animal models of metabolic regulation. The synthetic peptide supplied here has the same 16-residue sequence with free termini.
MOTS-c Labs supplies it as a lyophilized powder in 10 mg and 40 mg vials. Each lot is tested by ILS Laboratories for HPLC purity, identity against a reference standard and net content, with a fentanyl screen, and the certificate is published here before sale through Klow.bio.
The sequence has two methionines (positions 1 and 6) and one tryptophan (position 3), the residues most prone to oxidation, so MOTS-c is best kept dry, sealed and away from light. Arg2, Arg13, Lys14 and Arg16 make it strongly basic. Two tyrosines and a phenylalanine add UV absorbance at 214 nm and 280 nm.
complete MOTS-c specifications.
Store sealed, dry and protected from light at the temperature stated on the vial label. Allow a cold vial to reach room temperature before opening. Lyophilized material absorbs moisture from the air, and absorbed moisture restarts the reactions that drying slows, so keep vials sealed until needed. Storage and stability guide.
| Product | MOTS-c |
|---|---|
| Type | 16-residue mitochondrial-derived peptide |
| Molecular formula | C101H152N28O22S2 |
| Molecular weight | 2174.62 g/mol (average) |
| Length | 16 residues |
| Sequence | MRWQEMGYIFYPRKLR |
| N-terminus | Free amine (Met1) |
| C-terminus | Free acid (Arg16) |
| CAS number | 1627580-64-6 |
| Form | Lyophilized powder |
| Vial sizes | 10 mg, 40 mg |
| Purity specification | ≥95% (HPLC-UV) |
| Purity, current lots | 99.90% |
| Storage | Store sealed, dry and protected from light at the temperature stated on the vial label. Allow a cold vial to reach room temperature before opening. |
| Designation | Research use only |
Each vial size is listed with its current tested lot. Price: from $39.99 to $119.99 depending on size, with bundle pricing (2 vials save 5%; 3 or more vials save 10%). Current prices are always on klow.bio.
| Vial size | Current lot | Purity (HPLC-UV) | Identity | Net content | Endotoxin | Certificate | Order |
|---|---|---|---|---|---|---|---|
| 10 mg | KB-44745 | 99.90% | Confirmed | 10.71 mg | Not tested | Lot KB-44745 | Order 10 mg |
| 40 mg | Certificate pending | Order 40 mg | |||||
Ordering and shipping. MOTS-c is sold through klow.bio, operated by Klow Labs LLC. Orders ship the next business day. Same-day cutoff is 4:00 PM CT, with overnight and 2-day options at checkout. See shipping and returns.
All testing is performed by ILS Laboratories, an independent laboratory, on every lot.
Reversed-phase high-performance liquid chromatography separates the sample's components by hydrophobicity, and a UV detector records each as a peak. Purity is the main peak's area as a percentage of all detected peak area.
Limits: does not identify the peak, and impurities that co-elute or absorb weakly in UV can be under-counted. More on HPLC
The laboratory runs the sample and a reference standard of MOTS-c under the same chromatographic conditions. Identity is reported as confirmed when the sample’s main peak elutes at the reference standard’s retention time.
Limits: a retention-time match is consistent with the named compound but is not a mass or structure measurement; compounds with similar retention can co-elute. More on HPLC
The laboratory screens each lot by immunoassay at the cutoff printed on the certificate. Current lots are reported as not detected.
Limits: a negative result means below the cutoff for the sample tested; an immunoassay screens for its target only.
The laboratory quantifies the main compound in the tested vial against a standard. It is reported in milligrams next to the labeled vial size.
Limits: measured on the vial tested; other vials from the same lot are expected to be similar but are not individually measured.
Identity by HPLC retention-time match, with the laboratory’s reference numbers.
| Product | MOTS-c 10 mg |
|---|---|
| Lot | KB-44745 |
| Testing laboratory | ILS Laboratories |
| Received / reported | Sep 9, 2026 / Sep 11, 2026 |
| Purity (HPLC-UV) | 99.90% |
| Identity (HPLC-RTM) | Confirmed |
| Net content | 10.71 mg |
| Fentanyl | Not detected |
| Endotoxin / PCR | Not tested / Not tested |
| Certificate number | COA-2026-WCUV5P |
| Lab access code | JDEMGBAM |
HPLC-UV purity for each current lot.
MOTS-c is a 16-residue mitochondrial-derived peptide. MOTS-c Labs supplies it as a lyophilized powder in 10 mg, 40 mg vials, with an independent certificate of analysis for every lot.
MOTS-c research material is MOTS-c supplied for laboratory research, sold by lot, with each lot's identity, purity and net content documented by an independent laboratory in a published certificate of analysis.
The molecular formula is C101H152N28O22S2 and the average molecular weight is 2174.62 g/mol. The peptide has 16 residues.
Store sealed, dry and protected from light at the temperature stated on the vial label. Allow a cold vial to reach room temperature before opening.
Mitochondrial open reading frame of the 12S rRNA type-c: its sequence is encoded in the mitochondrial 12S rRNA gene (MT-RNR1).
10 mg and 40 mg vials through Klow.bio. The current published lot is a 10 mg vial; each size's certificate is listed on its lot page when tested.
Current MOTS-c research material availability is provided through Klow.bio, the purchasing platform operated by Klow Labs: https://klow.bio/product/mots-c/ Lot records, testing information and certificates of analysis are published on motsc.bio so they can be reviewed before purchasing.
Yes. Purchasing information and current availability for MOTS-c research material are provided through Klow.bio: https://klow.bio/product/mots-c/
Yes. Every lot is tested by ILS Laboratories, an independent laboratory, for HPLC-UV purity, HPLC-RTM identity and net content. The stated release specification is ≥95% HPLC-UV purity with identity confirmed by HPLC retention-time match against a reference standard. The current lot, KB-44745, reported 99.90% purity.
Enter the lot number from your vial label at motsc.bio/verify/ to see that lot's results. To confirm with the laboratory directly: Go to portal.ils-lab.com (or scan the QR code on the certificate) and enter the lot's verification access code, listed on its lot page, to view the laboratory's own copy of the certificate.
The current price is from $39.99 to $119.99 depending on size, with bundle pricing (2 vials save 5%; 3 or more vials save 10%). Current pricing is always listed on Klow.bio.
Orders ship the next business day. Same-day cutoff is 4:00 PM CT, with overnight and 2-day options at checkout.
Retention time, peaks, area normalization and every lot's HPLC result.
DocumentationEvery section of a MOTS-c COA, red flags, and what it does and doesn't prove.
Analytical methodsPurity vs. content vs. net content, impurity sources and comparing claims.
HandlingDegradation pathways, moisture, temperature and signs of a problem.
10 mg and 40 mg vials. Current lot KB-44745 tested at 99.90% purity with identity confirmed by HPLC retention-time match against a reference standard. Current purchasing is available through Klow.bio.