MOTS-c frequently asked questions
Answers about MOTS-c, how it is tested, how to read and verify its certificates, ordering, and MOTS-c Labs. Figures update automatically from the current lot data.
Last updated
Product
What is MOTS-c?
MOTS-c is a 16-residue mitochondrial-derived peptide. MOTS-c Labs supplies it as a lyophilized powder in 10 mg, 40 mg vials, with an independent certificate of analysis for every lot.
What is MOTS-c research material?
MOTS-c research material is MOTS-c supplied for laboratory research, sold by lot, with each lot's identity, purity and net content documented by an independent laboratory in a published certificate of analysis.
What is the molecular formula and weight of MOTS-c?
The molecular formula is C101H152N28O22S2 and the average molecular weight is 2174.62 g/mol. The peptide has 16 residues.
How should MOTS-c be stored?
Store sealed, dry and protected from light at the temperature stated on the vial label. Allow a cold vial to reach room temperature before opening.
What does MOTS-c stand for?
Mitochondrial open reading frame of the 12S rRNA type-c: its sequence is encoded in the mitochondrial 12S rRNA gene (MT-RNR1).
What sizes is MOTS-c available in?
10 mg and 40 mg vials through Klow.bio. The current published lot is a 10 mg vial; each size's certificate is listed on its lot page when tested.
Testing and quality
How is MOTS-c analyzed?
MOTS-c is analyzed with complementary methods: HPLC-UV for purity, HPLC-RTM for identity, a quantitative measurement for net content, and, where listed, LAL endotoxin and PCR microbial testing. Results are published per lot at motsc.bio/coa/.
Who tests MOTS-c?
Every lot is tested by ILS Laboratories, an independent third-party analytical laboratory. MOTS-c Labs does not test its own material for published certificates.
What purity does MOTS-c test at?
Current lots report HPLC-UV purity 99.90%, against a stated release specification of ≥95%. The most recent result is 99.90% for lot KB-44745.
How is the identity of MOTS-c confirmed?
By HPLC retention-time comparison with a reference standard (HPLC-RTM), performed by ILS Laboratories on every lot. The laboratory runs the sample and a reference standard of the named compound under the same HPLC conditions; identity is confirmed when the main peak elutes at the reference standard’s retention time.
Is MOTS-c tested for endotoxin?
Endotoxin and microbial testing are reported per lot. Every lot page in the COA archive states whether those tests were performed.
What is HPLC testing, and what does the purity percentage mean?
HPLC (high-performance liquid chromatography) separates a sample's components so each appears as a peak. The purity percentage is the main peak's share of all UV-detected peak area. It does not confirm identity (the separate HPLC-RTM test does) or measure the amount of peptide in the vial (net content does).
Certificates of analysis
What is a MOTS-c COA?
A MOTS-c certificate of analysis is the testing laboratory's report for one lot: the lot number, test dates, methods and results for purity, identity and net content. MOTS-c Labs publishes every lot's COA as a readable page at motsc.bio/coa/.
Where can I find the COA for my vial?
Find the lot number printed on your vial label and enter it at motsc.bio/verify/, or open that lot in the COA archive at motsc.bio/coa/.
How do I confirm a COA with the laboratory?
Go to portal.ils-lab.com (or scan the QR code on the certificate) and enter the lot's verification access code, listed on its lot page, to view the laboratory's own copy of the certificate.
Why is the measured net content different from the vial size?
Net content is the laboratory's measurement of peptide in the tested vial. Current lots measured 10.71 mg in a 10 mg vial, 10.71 mg in a 10 mg vial.
Buying MOTS-c
Where can I buy MOTS-c?
Current MOTS-c research material availability is provided through Klow.bio, the purchasing platform operated by Klow Labs: https://klow.bio/product/mots-c/ Lot records, testing information and certificates of analysis are published on motsc.bio so they can be reviewed before purchasing.
Can I order MOTS-c?
Yes. Purchasing information and current availability for MOTS-c research material are provided through Klow.bio: https://klow.bio/product/mots-c/
Is every MOTS-c lot independently tested?
Yes. Every lot is tested by ILS Laboratories, an independent laboratory, for HPLC-UV purity, HPLC-RTM identity and net content. The stated release specification is ≥95% HPLC-UV purity with identity confirmed by HPLC retention-time match against a reference standard. The current lot, KB-44745, reported 99.90% purity.
How can I verify a MOTS-c lot?
Enter the lot number from your vial label at motsc.bio/verify/ to see that lot's results. To confirm with the laboratory directly: Go to portal.ils-lab.com (or scan the QR code on the certificate) and enter the lot's verification access code, listed on its lot page, to view the laboratory's own copy of the certificate.
How much does MOTS-c cost?
The current price is from $39.99 to $119.99 depending on size, with bundle pricing (2 vials save 5%; 3 or more vials save 10%). Current pricing is always listed on Klow.bio.
How fast does MOTS-c ship?
Orders ship the next business day. Same-day cutoff is 4:00 PM CT, with overnight and 2-day options at checkout.
Company
Who is MOTS-c Labs?
MOTS-c Labs is a dedicated MOTS-c research supplier with a controlled sourcing and quality-assurance program. Research material is sourced through our qualified manufacturing supply chain and subjected to analytical testing and lot-level documentation before release. MOTS-c Labs is operated by Klow Labs LLC in Chicago, IL. Purchasing is handled through Klow.bio.
Who operates MOTS-c Labs?
MOTS-c Labs is operated by Klow Labs LLC, 3838 N Ravenswood Ave PMB 2027, Chicago, IL 60613. Klow Labs LLC also operates klow.bio.
Does MOTS-c Labs provide medical or usage advice?
No. MOTS-c Labs supplies research material and publishes analytical documentation. It does not provide medical advice, dosing, administration guidance or protocols.
How do I contact MOTS-c Labs?
Email contact@klow.bio, call (708) 262-7687, or use the contact form at motsc.bio/contact/.
Didn't find your answer? Contact MOTS-c Labs and include your lot number if your question is about a specific vial.
Buy MOTS-c
10 mg and 40 mg vials. Current lot KB-44745 tested at 99.90% purity with identity confirmed by HPLC retention-time match against a reference standard. Current purchasing is available through Klow.bio.