MOTS-c specifications and molecular characteristics
The technical specification for MOTS-c, the MOTS-c research material supplied by MOTS-c Labs: molecular formula C101H152N28O22S2, average molecular weight 2174.62 g/mol, 16 residues, supplied as a lyophilized powder. Each item is explained below.
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Specification table
| Product | MOTS-c |
|---|---|
| Type | 16-residue mitochondrial-derived peptide |
| Molecular formula | C101H152N28O22S2 |
| Molecular weight | 2174.62 g/mol (average) |
| Length | 16 residues |
| Sequence | MRWQEMGYIFYPRKLR |
| N-terminus | Free amine (Met1) |
| C-terminus | Free acid (Arg16) |
| CAS number | 1627580-64-6 |
| Form | Lyophilized powder |
| Vial sizes | 10 mg, 40 mg |
| Purity specification | ≥95% (HPLC-UV) |
| Purity, current lots | 99.90% |
| Identity specification | Confirmed by HPLC retention-time match |
| Testing laboratory | ILS Laboratories (independent) |
| Storage | Store sealed, dry and protected from light at the temperature stated on the vial label. Allow a cold vial to reach room temperature before opening. |
| Designation | Research use only |
Current lot results against specification
Every current lot meets the release specification. Current lots test at 99.90% by HPLC-UV against a specification of ≥95%, and identity is confirmed by HPLC retention-time match on every lot.
MOTS-c molecular formula
The molecular formula of MOTS-c is C101H152N28O22S2.
MOTS-c molecular weight
The average molecular weight of MOTS-c is 2174.62 g/mol. "Average" means it is calculated from natural isotope abundances.
MOTS-c sequence
MRWQEMGYIFYPRKLR
Structure and modifications
The sequence has two methionines (positions 1 and 6) and one tryptophan (position 3), the residues most prone to oxidation, so MOTS-c is best kept dry, sealed and away from light. Arg2, Arg13, Lys14 and Arg16 make it strongly basic. Two tyrosines and a phenylalanine add UV absorbance at 214 nm and 280 nm.
Physical form
Lyophilized powder, recorded as the appearance on every certificate. Lyophilization (freeze-drying) removes water, which slows most chemical degradation. What lyophilized means.
Purity and identity specifications
MOTS-c Labs’ stated release specification is ≥95% HPLC-UV purity with identity confirmed by HPLC retention-time match against a reference standard. The current lot, KB-44745, reported 99.90%. How purity is measured, or how specifications fit into the quality and supply-chain process.
Analytical and testing methods
HPLC-UV for purity, HPLC-RTM for identity and laboratory quantitation for net content, performed on every lot by ILS Laboratories. Each lot is also screened for fentanyl by immunoassay. LAL endotoxin testing (USP <85>) and PCR microbial screening are reported for lots where they were run. Testing and quality control.
Research designation
MOTS-c is designated research use only: supplied for laboratory research by qualified personnel. Research use only policy.
Buy MOTS-c
10 mg and 40 mg vials. Current lot KB-44745 tested at 99.90% purity with identity confirmed by HPLC retention-time match against a reference standard. Current purchasing is available through Klow.bio.